Endocrine Abstracts

Background: The initial L-T4 dose in the treatment of congenital hypothyroidism (CH) currently recommended is 10–15 mcg/kg/die.Objective: We designed a multicenter randomized trial to evaluate the effects of different starting dose of L-T4 within the range 10–15 mcg/kg/die on neurocognitive development in children with CH.Methods: Seventy-two children with CH diagnosed by neonatal screening were enrolled in the study. The...

Introduction: Maternal clinical thyroid disorders can cause reproductive complications. However, the effects of mild thyroid dysfunction are controversial. The impact of SH and thyroid autoimmunity on miscarriages, obstetric and perinatal outcomes are not yet well established and the effect of levothyroxine replacement in pregnant women with SH is unclear. The aim of this study was to evaluate the impact of thyroid autoimmunity in early pregnancy on obstetric and perinatal out...

Introduction: To date, benign thyroid nodules complainig of symptomatic or cosmetic problems and autonomous functioning thyroid nodules (AFTN) have generally been treated with surgery or I131. Radiofrequency ablation (RFA) is a novel technique that has demonstrated safety and efficacy in the treatment of these nodules. We describe the clinical experience at our hospital.Material and method: We include 33 patients (28 women, 5 men) from January 2013 to Se...

Cushing’s Syndrome (CS) is associated with a severe myopathy mainly affecting type 2 muscle fibres, with a higher prevalence in male subjects. The excess of glucocorticoids (GC) levels represents the most common cause of myopathy due to an alteration of protein metabolism. The non-coding post-transcriptional gene regulators muscle-specific microRNAs (miRNA) control muscle development and differentiation but when dysregulated lead to skeletal muscle (SM) disorder. The aim ...

Aims: We wanted to evaluate the correlations between the volume of the surgically removed parathyroid adenoma and the presurgical metabolic profile of patients diagnosed with primary hyperparathyroidism.Materials and methods: Prospective multicentric study, enrolling 52 patients with primary hyperparathyroidism from two medical units, proposed for surgery. Serum calcium and PTH were evaluated in all patients before surgery, and 25OH-D3 was measured only ...

The concurrence of glucose intolerance, hypertension, dyslipidemia and obesity has been termed metabolic syndrome. Each component of the metabolic syndrome is an independent risk factor for cardiovascular disease and diabetes type 2, the combination of these risk factors elevating the rates and severity of cardiac pathology.The therapeutic use of irbesartan, a selective blocker of the AT1 receptors, administered in arterial hypertension, coronary heart d...

HCC is a difficult-to-treat- cancer with poor prognosis. Despite EVOLVE-1 trial demonstrated that EVE did not improve overall survival in molecularly and clinically unselected patients with advanced sorafenib resistant HCC, in selected patients, the established antitumor effect of EVE could make this drug a potential adjuvant therapy. Unfortunately, the acquired EVE resistance due to the tumour adaptation to chronic drug use is a current challenge. VitD has been deemed as pote...

Introduction: The prevalence of acromegaly is estimated to be 6-28/100000 but several studies suggest that acromegaly is underdiagnosed and its prevalence is underestimated.Aim: To measure the prevalence of clinically relevant acromegaly in a well-defined population using data from 01.04.2004 to 01.11.2016.Method: Cross-sectional study performed in 8 counties from the North-East Romania. Data of patients with acromegaly were collec...

Primary adrenal non-Hodgkin lymphoma (PANHL) is extremely rare and constitutes <1% of all NHLs and 3% of extranodal lymphoma. PANHL affects predominantly elderly and males and could arises in the presence of a preexisting autoimmune adrenalitis. Diffuse large lymphomas of B-cell origin (DLBCL) histology is reported in 70% of PANHL cases.The present case is a primary, bilateral DLBCL of adrenal in 75-year-old male patient admitted for abdominal pain, ...

Hypocalcemia due to hypoparathyroidism leads to a large spectrum of clinical manifestations but a rare and unusual presentation is onset or aggravation of epilepsy.We report a 77-year-old man who was found to have profound hypocalcaemia and idiopatic hypoparathyroidism when investigated for epileptic seizures. He had affective disturbances and only mild neurocognitive disorders. Cataract was present. The neurological examination showed an extrapyramidal ...